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Research Progress of Exogenous Plant MiRNAs in Cross-kingdom Regulation

Author(s):

Hao Zhang*, Mengping Zhan, Haowu Chang, Shizeng Song, Chunhe Zhang and Yuanning Liu  

Abstract:


MiRNAs, involved in cell growth, differentiation, cycle regulation, play an important regulatory role in the life process. Research in this area has been widely concerned in RNAi research field. MiRNAs play an important role in the life process by influencing or regulating mRNA and key proteins in the process of cell proliferation and differentiation to involve in cell development. In particular, the regulations of human miRNAs in complex disease and epidemic have become the focus of life science, such as miRNAs and tumors, influenza viruses, and research in other immune systems. Studies have shown that exogenous miRNAs have cross-kingdom regulatory effects on bacteria and viruses, but whether exogenous plant miRNAs are stable in human body and participate in cross-kingdom regulation are still controversial. This review is discussing the most recent advances in the presence and pathway of exogenous plant miRNAs into human, and their cross-kingdom regulation.

Keywords:

Exogenous miRNAs, Cross-kingdom regulation, Absorption mechanism, Expression level, RT-PCR, Fluorescent labeling, Isotope labeling

Affiliation:

Computer Science and Technology Department, Symbol Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun, Computer Science and Technology Department, Symbol Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun, Computer Science and Technology Department, Symbol Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun, Computer Science and Technology Department, Symbol Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun, Computer Science and Technology Department, Symbol Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun, Computer Science and Technology Department, Symbol Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun



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