Submit Manuscript  

Article Details


Research on Gastric Cancer’s Drug-Resistant Gene Regulatory Network Model

Author(s):

Zhi Li, Tianyue Zhang, Haojie Lei, Liyan Wei, Yuanning Liu, Yadi Shi, Shuyi Li, Bowen Shen, Hao Guo, Zhangqian Chen, Xiaorong Yi and Hao Zhang*   Pages 1 - 10 ( 10 )

Abstract:


Based on bioinformatics, differentially expressed gene data of drug-resistance in gastric cancer were analyzed, screened and mined through modeling and network modeling to find valuable data associated with multi-drug resistance of gastric cancer. First, data sets were preprocessed from three aspects: data processing, data annotation and classification, and functional clustering. Secondly, based on the preprocessed data, each classified primary gene regulatory network was constructed by mining interactions among the genes. This paper computed the values of each node in each classified primary gene regulatory network and ranked these nodes according to their scores. On the basis of this, the appropriate core node was selected and the corresponding core network was developed. Finally, core network modules were analyzed, which were mined. After the correlation analysis, the result showed that the constructed network module had 20 core genes. This module contained valuable data associated with multi-drug resistance in gastric cancer.

Keywords:

Gastric cancer; multi-drug resistance; differentially expressed genes; gene regulatory networks.

Affiliation:

College of Computer Science and Technology, Jilin University, Changchun 130012, Jilin, College of Computer Science and Technology, Jilin University, Changchun 130012, Jilin, College of Computer Science and Technology, Jilin University, Changchun 130012, Jilin, College of Computer Science and Technology, Jilin University, Changchun 130012, Jilin, College of Computer Science and Technology, Jilin University, Changchun 130012, Jilin, School of Computer Science and Technology, Changchun University of Science and Technology, Changchun 130022, Jilin, School of Foreign Languages, Harbin Institute of Technology, Harbin 150001, Heilongjiang, College of Computer Science and Technology, Jilin University, Changchun 130012, Jilin, State key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi`an, State key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi`an, State key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi`an, College of Computer Science and Technology, Jilin University, Changchun 130012, Jilin



Read Full-Text article