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The Human OncoBiome Database: A database of cancer microbiome datasets

Author(s):

Nadia and Jayashree Ramana*  

Abstract:


The microbiome plays a very important role in many physiological processes including metabolism, inflammation, homeostasis and many biological pathways. So dysbiosis of the microbiome disrupts these pathways in different ways that result in cancer. There is a complex connection between the microbiome and cancer. Our bodies are continuously exposed to microbial cells, both resident and transient, as well as their byproducts, including toxic metabolites. We have developed the Human OncoBiome Database (HOBD) that provides a manually curated, searchable, metagenomic resource to facilitate investigation of Human Cancer microbiota and made it publicly accessible through web interface which will help further in metagenomic studies. In HOBD we have compiled the information of different cancers (Oral Cancer, Breast Cancer, Liver Cancer, Colorectal Cancer). The main purpose of creating HOBD is to provide the scientific community with comprehensive information on the species that play a crucial role in various Human Cancers. Over time this resource will grow to become a unique, community resource of human cancer bacteria, providing an extra level of annotation for analysis of metagenomic datasets. Our Database HOBD is different from Human Oral Microbiome database (HOMD) as the latter provides the comprehensive information about species that are present in the human oral cavity while the former is with regard to the species that are present in the various cancers. The HOBD site offers easy to use tools for viewing all publicly available Human Cancer microbiota. The freely accessible website is available at http://www.juit.ac.in/hcmd/home

Keywords:

Microbiome, Cancer, Database, Metagenomics, HOBD, OncoBiome

Affiliation:

Department of Biotechnology and Bioinfomatics, Jaypee University of Information Technology, Waknaghat- 173234, Solan (HP), Department of Biotechnology and Bioinfomatics, Jaypee University of Information Technology, Waknaghat- 173234, Solan (HP)



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