Azhwar Raghunath*, Raju Nagarajan and Ekambaram Perumal* Pages 1 - 5 ( 5 )
Background: Antioxidant response elements (ARE) play a key role in the expression of Nrf2 target genes by regulating the Keap1-Nrf2-ARE pathway, which offers protection against toxic agents and oxidative stress-induced diseases.
Objective: To develop a database of putative AREs for all the genes in the zebrafish genome. This database will be helpful for researchers to investigate Nrf2 regulatory mechanisms in detail.
Conclusion: ZFARED will be useful in the investigation of the Keap1-Nrf2-ARE pathway and its gene regulation. ZFARED is freely available at http://zfared.buc.edu.in/.
antioxidant response elements, database, Keap1-Nrf2-ARE pathway, Nrf 2, ZFARED, zebrafish
Molecular Toxicology Laboratory, Department of Biotechnology, Bharathiar University, Coimbatore 641 046, Tamilnadu, Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600 036, Tamilnadu, Molecular Toxicology Laboratory, Department of Biotechnology, Bharathiar University, Coimbatore 641 046, Tamilnadu