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The Regulation of Target Genes by Co-occupancy of Transcription Factors, c-Myc and Mxi1 with Max in the Mouse Cell Line

Author(s):

Hui Wang, Yuan Liu, Hua Guan and Guo-Liang Fan*   Pages 1 - 9 ( 9 )

Abstract:


The regulatory function of transcription factors on genes is not only related to the location of binding genes and its related functions, but is also related to the methods of binding. Different regulation effects will result in different binding methods on target genes. Transcription factors tend to combine with other transcription factors in the regulatory region to form a competitive or synergistic relationship to accurately regulate target genes. We found that up-regulated genes in cancer cells are involved in the regulation of their own immune system relative to the normal cells. In this study, we provide a reliable theoretical basis for studying gene expression regulation of co-binding transcription factors, and further reveal the specific regulation of transcription factor co-binding in cancer.

Keywords:

co-binding; motif; transcription factor; target genes

Affiliation:

Department of Physics, School of Physical Science and Technology, Inner Mongolia University, Hohhot, Department of Physics, School of Physical Science and Technology, Inner Mongolia University, Hohhot, ENT department, The First Hospital of Hohhot, Hohhot, Department of Physics, School of Physical Science and Technology, Inner Mongolia University, Hohhot



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