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Characterization and Prediction of Presynaptic and Postsynaptic Neurotoxin by Reduced Amino Acid and Biological Property.

Author(s):

Yiyin Cao, Chunlu Yu, Shenghui Huang, Shiyuan Wang, Yongchun Zuo and Lei Yang*   Pages 1 - 8 ( 8 )

Abstract:


Background: Presynaptic and postsynaptic neurotoxins are two important neurotoxins. Due to the important role of presynaptic and postsynaptic neurotoxins in pharmacology and neuroscience, identification of them becomes very important in biology.

Method: In this study, the statistical test and F-score were used to calculate the difference between amino acids and biological properties. The support vector machine was used to predict the presynaptic and postsynaptic neurotoxins by using the reduced amino acid alphabet types.

Results: By using the reduced amino acid alphabet as the input parameters of support vector machine, the overall accuracy of our classifier had increased to 91.07%, which was the highest overall accuracy in this study. When compared with the other published methods, better predictive results were obtained by our classifier.

Conclusion: In summary, we analyzed the differences between two neurotoxins in amino acids and biological properties, and constructed a classifier that could predict these two neurotoxins by using the reduced amino acid alphabet.

Keywords:

neurotoxin, reduced amino acid alphabet, biological property, support vector machine, machine learning, jackknife test

Affiliation:

College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, The State key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of life sciences, Inner Mongolia University, Hohhot, 010070, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, The State key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of life sciences, Inner Mongolia University, Hohhot, 010070, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081



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