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Exploring MiRNA Sponge Networks of breast cancer by Combining miRNA-disease-lncRNA and miRNA-target Networks

Author(s):

Lei Tian and Shu-Lin Wang*   Pages 1 - 10 ( 10 )

Abstract:


Background: Recently ample researches show that microRNAs (miRNAs) not only interact with coding genes but actually interact with a pool of different RNAs. Those RNAs are called miRNA sponges, including long non-coding RNAs (lncRNAs), circular RNA, pseudogenes and various messenger RNAs. Understanding regulatory networks of miRNA sponges can better help researchers to study the mechanisms of breast cancers.

Objective: We develop a new method to explore miRNA sponge networks of breast cancer by combining miRNAdisease-lncRNA and miRNA-target networks (MSNMDL).

Method: Firstly, MSNMDL infers miRNA-lncRNA functional similarity networks from miRNA-disease-lncRNA networks. Secondly, MSNMDL forms lncRNA-target networks by using lncRNA to replace the role of matched miRNA in miRNA-target networks according to the lncRNA-miRNA pair of miRNA-lncRNA functional similarity networks. And MSNMDL only retains the genes of breast cancer in lncRNA-target networks to construct candidate miRNA sponge networks. Thirdly, MSNMDL merges these candidate miRNA sponge networks with other miRNA sponge interactions and then selects top-hub lncRNA and its interactions to construct miRNA sponge networks.

Results: MSNMDL is superior to other methods in terms of biological significance and its identified modules might act as module signatures for prognostication of breast cancer.

Conclusion: MiRNA sponge networks identified by MSNMDL are biologically significant and are closely associated with breast cancer, which makes MSNMDL a promising way for researchers to study the pathogenesis of breast cancer.

Keywords:

MiRNA sponge networks, MiRNA sponge modules, Breast cancer, Biological Enrichment, Clustering algorithm.

Affiliation:

School of Information Science and Engineering, Hunan University, Changsha, School of Information Science and Engineering, Hunan University, Changsha



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