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Identification of key lncRNAs and mRNAs Associated with Oral Squamous Cell Carcinoma Progression

Author(s):

Ju Li, Congcong Zhang, Yang Shi, Qing Li, Na Li and Yong Mi*   Pages 1 - 9 ( 9 )

Abstract:


Background: Oral squamous cell carcinoma (OSCC) had been the sixth most common cancer worldwide. Emerging studies showed long non-coding RNAs played a key role in human cancers. However, the molecular mechanisms underlying the initiation and progression of OSCC remained to be further explored.

Objective: The present study aimed to identify differentially expressed lncRNAs and mRNAs in OSCC.

Methods: GSE30784 was analyzed to identify differentially expressed lncRNAs and mRNAs in OSCC. Protein-protein interaction network and co-expression network analysis were performed to reveal the potential roles of OSCC related mRNAs and lncRNAs.

Results: In present study, we identified 21 up-regulated lncRNAs and 54 down-regulated lncRNAs in OSCC progression. Next we constructed a lncRNA related co-expression network in OSCC, which included 692 mRNAs and 2193 edges. Bioinformatics analysis showed lncRNAs were widely co-expressing with regulating type I interferon signaling pathway, extracellular matrix organization, collagen catabolic process, immune response, ECM-receptor interaction, Focal adhesion, and PI3K-Akt signaling pathway. A key network, included lncRNA C5orf66-AS1, C21orf15, LOC100506098, PCBP1-AS1, LOC284825, OR7E14P, HCG22, and FLG-AS1, were found to be involved in the regulation of immune response to tumor cell, Golgi calcium ion transport, negative regulation of vitamin D receptor signaling pathway, glycerol-3-phosphate catabolic process. Moreover, we found showed higher expression of CYP4F29P, PCBP1-AS1, HCG22, and C5orf66-AS1were associated with shorter overall survival time in OSCC samples.

Conclusions: We thought our analysis could provide novel insights to explore the potential mechanisms underlying OSCC progression

Keywords:

Long non-coding RNAs, oral squamous cell carcinoma, protein-protein interaction analysis, co-expression analysis, biomarker.

Affiliation:

Jinan Stomatological Hospital, 101 Jingliu Road, Jinan 250001, Shandong, Jinan Stomatological Hospital, 101 Jingliu Road, Jinan 250001, Shandong, Jinan Stomatological Hospital, 101 Jingliu Road, Jinan 250001, Shandong, Jinan Stomatological Hospital, 101 Jingliu Road, Jinan 250001, Shandong, Jinan Stomatological Hospital, 101 Jingliu Road, Jinan 250001, Shandong, Jinan Stomatological Hospital, 101 Jingliu Road, Jinan 250001, Shandong



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