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Bio-analytical Identification of Key Genes that Could Contribute to the Progression and Metastasis of Osteosarcoma

Author(s):

Fei Wang, Guoqing Qin, Junzhi Liu, Xiunan Wang and Baoguo Ye*   Pages 1 - 9 ( 9 )

Abstract:


Background: Osteosarcoma (OS) is one of the most common primary malignant bone tumors in children and adolescents. OS metastasis has been a challenge for the treatment of OS The present study screened progression related genes in OS by analyzing a public dataset GSE42352, and identified 691 up-regulated and 945 down-regulated genes in advanced stage OS compared to early stage OS samples.

Methods: Protein-protein interaction (PPI) networks were further conducted to reveal the interaction among these genes. Bioinformatics analysis showed that progression related differently expressed genes (DEGs) were significantly associated with the regulation of cell proliferation and metabolisms.

Results: This study revealed progression related DEGs were dysregulated in metastatic OS compared to non-metastatic OS samples. Further analysis showed CSF1R, CASP1, CD163, AP1B1, LAPTM5, PEX19, SLA, STAB1, YWHAH, PLCB2, and GPR84 were associated with the metastasis free survival time in patient with OS.

Conclusions: These findings provided novel information for us to understand the mechanisms underlying the progression and metastasis of OS.

Keywords:

Osteosarcoma, metastasis, Bioinformatics analysis, signaling pathway

Affiliation:

Department of Orthopedics, China-Japan Union Hospital Jilin University, Changchun,Jilin, Department of Orthopedics, Jilin Disabled Persons' Rehabilitation Center, (Jilin Chunguang Rehabilitation Hospital),Changchun,Jilin, Quality Control Department, China-Japan Union Hospital Jilin University, Changchun, Jilin, Department of Orthopedics, The 964th Hospital of the PLA Joint Logistics Support Force, No. 4799 Xi 'an Road, Lvyuan District, Changchun City, Jilin Province, Department of Anesthesiology, China-Japan Union Hospital Jilin University, Changchun,Jilin



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