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MDAPlatform: A Component-based Platform for Constructing and Assessing miRNA-disease Association Prediction Methods

Author(s):

Yayan Zhang, Guihua Duan, Cheng Yan*, Haolun Yi, Fang-Xiang Wu and Jianxin Wang   Pages 1 - 12 ( 12 )

Abstract:


Background: Increasing evidence has indicated that miRNA-disease association prediction plays a critical role in the study of clinical drugs. Researchers have proposed many computational models for miRNA-disease prediction. However, there is no unified platform to compare and analyze the pros and cons or share the code and data of these models.

Objective: In this study, we develop an easy-to-use platform (MDAPlatform) to construct and assess miRNA-disease association prediction method.

Methods: MDAPlatform integrates the relevant data of miRNA, disease and miRNA-disease associations that are used in previous miRNA-disease association prediction studies. Based on the componentized model, it develops differet components of previous computational methods.

Results: Users can conduct cross validation experiments and compare their methods with other methods, and the visualized comparison results are also provided.

Conclusion: Based on the componentized model, MDAPlatform provides easy-to-operate interfaces to construct the miRNA-disease association method, which is beneficial to develop new miRNA-disease association prediction methods in the future.

Keywords:

MiRNA, Disease, MicroRNA-disease association, Constructing prediction methods, Cross-language, Componentbased platform.

Affiliation:

Hunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University, 932 South Lushan Rd, 410083, ChangSha,, Hunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University, 932 South Lushan Rd, 410083, ChangSha,, School of Computer and Information, Qiannan Normal University for Nationalities, Longshan Road, 558000, Duyun,, Hunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University, 932 South Lushan Rd, 410083, ChangSha,, Division of Biomedical Engineering and Department of Mechanical Engineering, University of Saskatchewan, SKS7N5A9, Saskatoon,, Hunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University, 932 South Lushan Rd, 410083, ChangSha



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