Yingying Wang, Yu Yang, Jianfeng Liu and Keshen Li* Pages 1 - 10 ( 10 )
Background: Human brain development is a series of complex processes that exhibit profound changes from gestation to adulthood.Objective: We aimed to construct dynamic developmental networks for each anatomical structure of the human brain based on omics’ levels in order to gain a new systematical brain map at the molecular level. Method: We performed the brain development analysis by constructing dynamical networks between adjacent time points on different grouping levels of anatomical structures. The gene-time networks were first built to obtain the developing brain dynamical maps on the transcriptome level. Then miRNA-mRNA networks and protein-protein networks were constructed by integrating the information from miRNomics and proteomics. The time- and structure-specific biomarkers were filtered based on analyses of topological characters. Results: The most dramatic developmental time and structure were fetal-infancy and telencephalon, respectively. Cortex was the key developmental region in ‘late fetal and neonatal’ and ‘early infancy’ stages. The development of temporal lobe was different from other lobes since significant changes in molecules were found only in the comparison pair ‘early fetal-early mid-fetal’ and ‘adolescence-young adulthood’. Interestingly, the changes among different brain structures inside adolescence and adulthood were bigger than other time points. hsa-miR-548c-3p and H3C2 may be new brain development indicators considering their key roles in networks. Conclusion: To our knowledge, this study is the first report of dynamical brain development maps for different anatomical structures on multiple omics. The results provide a new perspective on brain development in a systematical way which may provide a more accurate understanding of the human brain.
Dynamical network, brain development, multiple omics, brain map, time-specific, structure-specific.
Department of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou, Department of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou, Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, Department of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou