Aditya Rao, Sri Jyothsna Yeleswarapu, Rajgopal Srinivasan and Gopalakrishnan Bulusu Pages 66 - 73 ( 8 )
Proteins localize to many intracellular and extracellular organelles in the malarial parasite Plasmodium falciparum. Although organellar localization in the parasite has been studied in detail, there is a need for a comprehensive ruleset that captures the different paths and mechanisms used by proteins for localization. This review is an attempt to build such a rule-set through a combination of rules gleaned from literature reports. A prototype localization prediction tool has also been implemented by incorporating certain sequence/composition rules from the rule-set.
Plasmodium falciparum, protein localization, integrated rule-set, Targetpf
Life Sciences Division, TCS Innovation Labs Hyderabad, Tata Consultancy Services Ltd, 1, Software Units Layout, Madhapur, Hyderabad 500081, India.