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An Integrated Rule-Set for Protein Localization in Plasmodium falciparum

[ Vol. 3 , Issue. 2 ]

Author(s):

Aditya Rao, Sri Jyothsna Yeleswarapu, Rajgopal Srinivasan and Gopalakrishnan Bulusu   Pages 66 - 73 ( 8 )

Abstract:


Proteins localize to many intracellular and extracellular organelles in the malarial parasite Plasmodium falciparum. Although organellar localization in the parasite has been studied in detail, there is a need for a comprehensive ruleset that captures the different paths and mechanisms used by proteins for localization. This review is an attempt to build such a rule-set through a combination of rules gleaned from literature reports. A prototype localization prediction tool has also been implemented by incorporating certain sequence/composition rules from the rule-set.

Keywords:

Plasmodium falciparum, protein localization, integrated rule-set, Targetpf

Affiliation:

Life Sciences Division, TCS Innovation Labs Hyderabad, Tata Consultancy Services Ltd, 1, Software Units Layout, Madhapur, Hyderabad 500081, India.



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