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The Regulation of Target Genes by Co-occupancy of Transcription Factors, c-Myc and Mxi1 with Max in the Mouse Cell Line

[ Vol. 15 , Issue. 6 ]

Author(s):

Hui Wang, Yuan Liu, Hua Guan* and Guo-Liang Fan*   Pages 581 - 588 ( 8 )

Abstract:


Background: The regulatory function of transcription factors on genes is not only related to the location of binding genes and its related functions, but is also related to the methods of binding.

Objective: It is necessary to study the regulation effects in different binding methods on target genes.

Methods: In this study, we provided a reliable theoretical basis for studying gene expression regulation of co-binding transcription factors and further revealed the specific regulation of transcription factor co-binding in cancer cells.

Results: Transcription factors tend to combine with other transcription factors in the regulatory region to form a competitive or synergistic relationship to regulate target genes accurately.

Conclusion: We found that up-regulated genes in cancer cells were involved in the regulation of their own immune system related to the normal cells.

Keywords:

Co-binding, transcription factor, target genes, synergistic, immunity system, cancer cells.

Affiliation:

Department of Physics, School of Physical Science and Technology, Inner Mongolia University, Hohhot, Department of Physics, School of Physical Science and Technology, Inner Mongolia University, Hohhot, ENT Department, Huhhot First Hospital, Hohhot, Department of Physics, School of Physical Science and Technology, Inner Mongolia University, Hohhot

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