Raha Pazoki, Michael W.T. Tanck, Arthur A.M. Wilde and Connie R. Bezzina Pages 6864 - 6872 ( 9 )
Sudden cardiac death (SCD) from ventricular fibrillation during myocardial infarction is a leading cause of total and cardiovascular mortality. It has a multifactorial, complex nature and aggregates in families, implicating the involvement of heritable factors in the determination of risk. During the last few years, genome-wide association studies have uncovered common genetic variants modulating risk of SCD. We here review the current insight on genetic determinants of SCD in the community and describe the genome-wide association approaches undertaken thus far in uncovering genetic determinants of SCD risk.
Ventricular arrhythmia, genome-wide association studies, sudden cardiac death, genetics.
, , , Department of Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center Amsterdam (AMC), PO Box 22660, 1100 DD Amsterdam, The Netherlands