Ruthenium(II) Complexes as Potential Apoptosis Inducers in Chemotherapy

Author(s):

Kangdi Zheng, Qiong Wu, Chengxi Wang, Weijun Tan and Wenjie Mei   Pages 29 - 39 ( 11 )

Abstract:

Herein, the development of ruthenium complexes as potential apoptosis inducers, as well as their underlying mechanism has been reviewed. In recent years, various ruthenium complexes have been designed and their in vitro and in vivo inhibitory activities against various types of tumor cells have been evaluated extensively. It’s demonstrated that ruthenium complexes can induce apoptosis of tumor cells through the signal pathway of mitochondria-mediated, death receptor-mediated, and/or endoplasmic reticulum (ER) stress pathways. Alternately, the binding behavior of these ruthenium(II) complexes with DNA, especially with Gquadruplex DNA may play a key role in the DNA damage of tumor cells, and thus provides a versatile tool to rational design novel ruthenium complexes with high activity and selectivity.

Keywords:

Ruthenium complexes, apoptosis, mitochondria, G-quadruplex, endoplasmic reticulum.

Affiliation:

, , , School of Food Science, Guangdong Pharmaceutical University, Zhongshan 528458, China., Department of School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.

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